Projects

Projects

LVTI develops open-source infrastructure, standards, and governance for virtual human twin technology.
Below are the initiatives currently in development. Each project is grounded in the Living Heart Project’s
decade-long track record and Steve Levine’s ongoing collaboration with the FDA through the ENRICHMENT program.

Virtual Human ATLAS

AI-Ready Twin Library for Anatomy and Simulation

Proposal in Development
OS4LS Track 2 — Foundational Libraries
24-Month Scope

Cardiovascular disease is the leading cause of death in the United States and claims nearly 18 million lives
globally each year, yet cardiovascular research receives less than half the NIH funding directed to cancer.
The fastest path forward is not more funding alone — it is multiplying the return on the research that already exists.

The Virtual Human ATLAS is a proposed open-source initiative that would build on more than a decade of work
from the Living Heart Project to create a shared interoperability and credibility layer for virtual human organ models.
The goal is to make existing models — built by research teams across more than 150 organizations in 24 countries —
discoverable, composable, and legible to both researchers and AI-driven workflows.

ATLAS would not create new science. It would formalize the open-source code, datasets, and validated methods
already generated by the Living Heart Project ecosystem, making them machine-readable, AI-ready, and directly
connected to FDA regulatory credibility standards through the ENRICHMENT framework — a program co-led by
Steven Levine and the U.S. FDA.

The ENRICHMENT connection is what sets ATLAS apart. No other open-source project holds both the technical
maintainer role in this ecosystem and direct co-authorship of the regulatory credibility framework it encodes.
Regulatory credibility becomes a queryable property of the model — not a narrative attached to it.

Proposed Workstreams

Core Schema Specification
Formalize existing data structures into a modular schema covering anatomy, solver configuration, outputs, provenance, and AI-readiness metadata.
Open-Source Python Validator
Build opentwin-python, a reference library for schema validation, metadata extraction, credibility-report generation, and machine-readable exports.
Living Heart Reference Implementation
Package widely used Living Heart resources into the ATLAS format as a gold-standard demonstration, including ENRICHMENT-derived credibility structures.
Community Adoption Toolkit
Documentation, tutorials, and a self-service toolkit enabling external organ modeling communities to package their models to the ATLAS specification independently.
Principal Investigator: Steven Levine   
Organization: Living Virtual Twin Institute (LVTI), a registered 501(c)(3) nonprofit   
Funding Sought: $1,000,000