The Living Virtual  Twin Project is a global nonprofit initiative to unite the world’s leading researchers, clinicians, technologists, and regulatory bodies towards the construction of an integrated, modular, and validated Virtual Human Twin platform. Inspired by the success of the Living Heart Project, which demonstrated how a loosely coordinated, standards-driven collaborative platform can amplify resource and funding effectiveness, to rapidly deliver impactful science, sustainable innovation, and regulatory influence. We are scaling this model to all major organ systems towards a full human twin.

Each organ model is developed independently by multidisciplinary teams and designed to interoperate through defined virtual biological interfaces, enabling an efficient platform for multi-organ testing and one day whole-body simulation. This system-level approach allows for better drug development, personalized medicine, and predictive diagnostics, replacing fragmentation with functional synergy.

To support transparency, credibility, and adoption we will operate a peer-reviewed, open-access journal dedicated to advancing the science, credibility, and interoperability of virtual human models. It will serve as the authoritative repository for model construction methods, validation protocols, defined contexts of use, and where possible the models themselves. By aligning submissions to a common framework, the journal will ensure consistency, transparency, and reusability across contributions, becoming the living blueprint for the virtual human as it is built organ by organ, system by system.

We don’t own the models, rather we coordinate the ecosystem. By providing governance, shared standards, and an open platform, we unlock the full value of distributed expertise and ensure models are trustworthy, reusable, and clinically relevant.

The result: a transformative resource for research, regulation, and healthcare that enhances ethics, accelerates innovation, lowers the cost by redefining how we understand and treat the human body.